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  • Rated by damaldumil on Oct 07 2007, 11:58pm

    At this point, we are working under the conviction that our opinions on aPKC and PKB are correct, and we optimistically believe that we are at, or close to, an understanding of why insulin fails to work effectively in stimulating glucose uptake in muscle and, on the other hand, is overactive in stimulating lipid synthesis in the liver in insulin-resistant hyperinsulinemic states. Accordingly, we believe that we are on the threshold for devising better programs for treating the "metabolic" or "insulin resistance" syndrome seen in obesity and Type II diabetes mellitus.