Around 25 people are feared trapped in a block of flats after a fire swept through the building.
More than 100 firefighters were tackling the blaze at the 12-storey tower block in Camberwell, south London.
A fire brigade spokesman said seven floors were on fire.
Emergency services were called to Lakanal House in Havil Street at 4.20pm on Friday.
A spokesman for London Fire Brigade said 18 fire engines were sent to the scene as well as an aerial ladder platform, ground monitor and breathing apparatus.
He said: "Floors five to 11 are involved in fire and heavy smoke logging. 25 persons are believed involved. Efforts are being made to rescue them."
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