pseudonym/biology

Look inside a cell.

From the page: "They are attempting to breed pigs that have been genetically modified so that porcine organs are accepted by the human body instead of being immediately rejected.

Human immune systems are quick to react to "foreign bodies" but the scientists are confident that they are close to modifying the genetic make-up of pigs to "humanise" their organs and make animal-to-human transplants possible.

The humanisation process of the organs is expected to be achieved by breeding genes into the pigs, probably by injecting them directly into the parent boar's testicles, that provoke a greatly reduced response in the patient's immune system.

Patients who received pig organs would have to take immune suppressant drugs for the rest of their lives, but no more than those who received organ transplants from other people."

From the page: "Although the link between pollutants and human reproduction has not been firmly established, there is growing evidence that the birth sex ratio can be altered by exposure to certain chemicals, such as dioxin, PCBs and pesticides. Brophy said studies done in the United States, Japan and Europe seem to support the theory that the so-called endocrine disrupting chemicals have a particular effect on males.

Some of these chemicals are found in commonly used products such as baby bottles and cosmetics. They can also cause miscarriages and a "whole host" of disorders in a male child, Brophy said."

From the page: "Over the summer, Szostak's team published major papers in the journals Nature and the Proceedings of the National Academy of Sciences that go a long way towards showing that this isn't just an idea and that his lab will be the first to create artificial life -- and that it will happen soon.

"His hope is that he'll have a complete self-replicating system in his lab in the near future," said Jeffrey Bada, a University of California San Diego chemist who helped organize the Origin of Life conference.

Modern life is far more complex than the simple systems that Szostak and others are working on, so the protocells don't look anything like the cells that we have in our bodies or Venter's genetically-modified E. coli.

"What we're looking at is the origin of life in one aspect, and the other aspect is life as a small nanomachine on a single cell level," said Hans Ziock, a protocellular researcher at Los Alamos National Laboratory.

Life's function, as a simple nanomachine, is just to use energy to marshal chemicals into making more copies of itself.

"You need to organize yourself in a specific way to be useful," Ziock said. "You take energy from one place and move it to a place where it usually doesn't want to go, so you can actually organize things."

Modern cells accomplish this feat with an immense amount of molecular machinery. In fact, some of the chemical syntheses that simple plants and algae can accomplish far outstrip human technologies. Even the most primitive forms of life possess protein machines that allow them to import nutrients across their complex cell membranes and build the molecules that then carry out the cell's bidding.

Those specialized components would have taken many, many generations to evolve, said Ziock, so the first life would have been much simpler."