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Injectable Nano-Network for Glucose-Mediated Insulin Delivery

Wed, 15 May 2013 08:53:51 -0700

From the page: "Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world. An artificial âoeclosed-loopâ system able to mimic pancreas activity and release insulin in response to glucose level changes has the potential to improve patient compliance and health. Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network. Formed by electrostatic interaction between oppositely charged dextran nanoparticles loaded with insulin and glucose-specific enzymes, the nanocomposite-based porous architecture can be dissociated and subsequently release insulin in a hyperglycemic state through the catalytic conversion of glucose into gluconic acid. In vitro insulin release can be modulated in a pulsatile profile in response to glucose concentrations. In vivo studies validated that these formulations provided improved glucose control in type 1 diabetic mice subcutaneously administered with a degradable nano-network. A single injection of the developed nano-network facilitated stabilization of the blood glucose levels in the normoglycemic state (<200 mg/dL) for up to 10 days."

Page or Resource Not Found - The Writer Magazine

Tue, 14 May 2013 03:58:49 -0700

From the page: "6. Check my website for a quote. When you窶ve landed an interview, no matter how big or small, go into it with the attitude of providing as much information as you possibly can and making life easy for journalists. The truth is, journalists have weekly, sometimes daily, deadlines, and most don窶t have time to comprehensively examine your book. Be helpful and provide quotes from the book because the journalist will put your name and your book窶s name in her article, and readers, who do have the time and the inc"

The Body-Brain Connection: Does Your Sedentary Lifestyle Damage Your Writing Talent?

Tue, 14 May 2013 03:53:35 -0700

From the page: "Take a hike! According to a study referenced in Scientific American, participants who spent four days hiking without electronic devices scored nearly fifty percent higher on creativity tests than a control group. Fifty percent is a HUGE difference. It may not be possible to go hiking in the woods for four days, but it is possible to incorporate the concept into your daily life. Take a few moments each day to stroll around your yard or the grounds of your apartment complex WITHOUT your cell or smartphone. The walking will fulfill the need for more movement, while the daily observing of the world around you will serve to inspire your writing. **NOTE: If you regularly work out with apps on your smartphone, we recommend that you silence your ringtone/notifications so you are free of distractions and can let the creativity flow more freely through your mind."

Sister Corita Kent's Timeless Rules for Learning and Life, Hand-Lettered by Lisa Congdon

Sun, 12 May 2013 11:07:53 -0700

From the page: "Sister Corita Kentâs Timeless Rules for Learning and Life, Hand-Lettered by Lisa Congdon by Maria Popova âoeItâs the people who do all of the work all the time who eventually catch on to things.â"

Returned Kiwis want acclaim

Sun, 12 May 2013 02:46:44 -0700

From the page: "Lee, who has just completed a Masters degree in the subject from Massey University, says we know very little about those who actually do return. On a recent online discussion created by KEA - a non-profit organisation dedicated to leveraging expat Kiwis' contribution to New Zealand - returning expats were surprised at the little value potential employers placed on what they have to offer. Many said employers were even fearful of hiring them. "I was actually told by several people that I didn't get the job because the manager perceived that I knew more than he did and therefore felt threatened," one return migrant said."

Re:Focus: Marketing

Sat, 11 May 2013 13:49:01 -0700

From the page: "Communicating in short, simple emotionally charged messages is essential for stimulating the Limbic Brain. Unlike the neocortex, our mammalian brain is actually incapable of processing much information. More than driving an impulse or decision, the Limbic Brain is also responsible for our feelings of loyalty, love and devotion. So not only are Nike, Apple and Bill Clinton able to drive choice with their simple emotionally charges messages, they are able to create loyalty so strong that even rational arguments can not unseat those feelings."

Green Car Congress: New ionic liquid biomass pretreatment method eliminates need for enzymes, reduces water use

Thu, 09 May 2013 11:52:17 -0700

From the page: "New ionic liquid biomass pretreatment method eliminates need for enzymes, reduces water use 9 May 2013 Simmons-biphasic The new ionic liquid pretreatment of cellulosic biomass yields a biphasic solution, a lower phase rich in sugar and an upper phases rich in ionic liquid. (Courtesy of Simmons/JBEI) Click to enlarge. Researchers at the US Department of Energy (DOE)窶s Joint BioEnergy Institute (JBEI) have developed a new technique for pre-treating cellulosic biomass with ionic liquids that could reduce the cost of producing advanced biofuels from plant sugars. This new technique requires none of the expensive enzymes used in previous ionic liquid pretreatments, and yields a biphasic solution窶"a lower phase rich in sugar and an upper phases rich in ionic liquid窶"making it easier to recover fuel sugars and recycle the ionic liquid. An open access paper describing this research has been published in the journal Biotechnology for Biofuels. "

Who's number 1? Really?

Tue, 30 Apr 2013 05:01:17 -0700

From the page: "WHAT country's non-native English-speakers speak the best business English in the world? Try to think of five countries before reading on. Done? The answer, according to GlobalEnglish, is probably not what you think. (GlobalEnglish is owned by Pearson, which part-owns The Economist). "

Sir Winston Churchill Quotes - The Quotations Page

Mon, 29 Apr 2013 03:11:15 -0700

From the page: "One ought never to turn one's back on a threatened danger and try to run away from it. If you do that, you will double the danger. But if you meet it promptly and without flinching, you will reduce the danger by half. [info][add][mail][note] Sir Winston Churchill"

NORTHWEST TERRITORIES: Inuvik Community Greenhouse

Sun, 28 Apr 2013 01:10:21 -0700

The most northerly glass house